Table 2.
Patients and tumor characteristics in dependence of the intratumoral OCT1 mRNA expression
| Characteristics | OCT1 (SLC22A1) Low expression (< Median) |
OCT1 (SLC22A1) High expression (≥ Median) |
P-value |
|---|---|---|---|
| N | 27 | 26 | |
| Median follow-up in days (range) | 434 (22-1538) | 425 (109-1645) | n.s. (0.20) |
| Male/female (n) | 23/4 | 23/3 | n.s. (1.00) |
| Median age in years (range) | 69 (35-86) | 67 (47-93) | n.s. (0.35) |
| 1-3 nodules/multiple nodules (specimen) | 18/9 | 18/8 | n.s. (1.00) |
| Tumor diameter < 3 cm/> 3 cm | 5/22 | 14/12 | 0.010 |
| Median tumor diameter in cm (range) | 6.0 (1.5-30) | 2.8 (0.1-20) | 0.035 |
| T classification: T1/T2/T3 (specimen) | 8/7/12 | 10/13/3 | 0.025 |
| Grading: G1/G2/G3/Gx | 1/17/9/0 | 10/14/1/1 | 0.001 |
| AFP > 100/< 100 * | 9/16 | 2/24 | 0.019 |
| Angioinvasion yes/no # | 7/16 | 4/22 | n.s. (0.31) |
| Child A/B/C/no cirrhosis | 10/1/1/15 | 9/3/6/8 | n.s. (0.08) |
| Underlying disease (HCV/HBV/alcoholic/others/unknown) | 4/2/1/10/10 | 6/7/3/5/5 | n.s. (0.11) |
|
SLC22A3 mRNA expression ratio HCC/TST (range) |
0.21 (0.001-3.07) |
0.86 (0.33-3.12) |
0.008 |
| Pretreatment with chemoembolization (yes/no) | 2/25 | 18/8 | < 0.001 |
| Liver transplantation/resection | 4/23 | 16/10 | 0.001 |
Median: 0.112 * 2 unknown # 4 unknown