Figure 3. CLU1 and CLU2 encoded proteins are localized to the ER and Golgi.

SH-SY5Y cells were transfected with vectors encoding CLU1 and CLU2; the resultant clusterin expression was localized by a vector-derived V5 epitope tag. The subcellular localization for both proteins overlapped with the Golgi, as shown by co-labeling with antibody against TGN46 (A) and with the ER, as shown by co-labeling with an antibody against calnexin (B).