Table 2. Analysis of CLU1 Expression.

Parameter	Coeff.	SE	P value
AD Neuropathology	0.01675	0.00551	0.004
Rs11136000 (dominant model)	0.01927	0.00798	0.020
Sex	−0.00708	0.01503	0.640
Age	−0.00112	0.00104	0.286

CLU1 expression was analyzed as a function of rs1136000, AD neuropathology, sex and age by using a general linear model. This model assumed a dominant mode of inheritance for the SNP. The estimated marginal means for CLU1 in rs11136000 CC versus CT/TT individuals were 0.112±0.013 and 0.151±0.010 (mean ± SE), respectively. The estimated marginal means for low and high AD neuropathology were 0.106±0.014 and 0.157±0.009 (mean ±SE), respectively. These values were modeled with age equal to 82.3 years.