Table 3. Analysis of CLU2 Expression.

Parameter	Coeff.	SE	P value
AD Neuropathology	0.06482	0.02483	0.012
Rs11136000 (dominant model)	0.00697	0.03594	0.847
Sex	0.03399	0.06766	0.618
Age	−0.01024	0.00467	0.033

CLU2 expression was analyzed as a function of rs1136000, AD neuropathology, sex and age by using a general linear model. A dominant mode of inheritance was assumed for rs11136000. The estimated marginal means for low and high AD neuropathology were 0.332±0.062 and 0.526±0.041 (mean ±SE), respectively. These values were modeled with age equal to 82.3 years.