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. 2012 Apr 10;7(4):e33660. doi: 10.1371/journal.pone.0033660

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Shaw et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by cerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF Percentage). The volume of the cerebellum is expressed as a percentage of the total brain volume (Cerebellar Brain Percentage). Fitted linear regression lines are also displayed. Cavalier King Charles Spaniels (CKCS) showed a relationship between cerebellar crowding and volume in both the rostral CCF (p = 0.0008) and caudal CCF (p = 0.0003) and Labradors (LD) and small breed dogs (SB) did not. In CKCS the slope of the fitted model in the caudal CCF was significantly steeper than in the rostral CCF (p = 0.03668), indicating that crowding in the caudal CCF is more sensitive to changes in cerebellar volume.