Figure 2. AIRE^−/− mice reject tumour more efficiently than AIRE^+/+ littermate controls mice after priming.

A Mice of indicated genotype were challenged with B16F10, and tumour growth monitored over 75 days. B As treated in A, but mice were primed with irradiated B16F10 4 weeks prior to challenge. Curves were compared with Logrank test with p values indicated. Similar trends were found in at least 5 different experiments. In each of these experiments between 5 and 10 mice/group were included.