Table 1.
BMI <40 (n=256) | BMI ≥40 (n=158) | ||||
---|---|---|---|---|---|
Demographics/risk factors | N or median | % or range | N or median | % or range | pValue |
Age, y | 29.5 | [13–62] | 28 | [13–59] | 0.37 |
Gender [M/F] | 15/241 | [5.9%/94.1%] | 16/142 | [10.1%/89.9%] | 0.10 |
Race | 0.10 | ||||
Black | 104 | [40.6%] | 77 | [48.7%] | |
Non-black | 152 | [59.4%] | 81 | [51.3%] | |
Contributing medications* | 21 | [8.2%] | 13 | [8.2%] | 0.99 |
Sleep Apnea | 13 | [5.1%] | 26 | [16.5%] | <0.001 |
Anemia | 14 | [5.5%] | 13 | [8.2%] | 0.26 |
Endocrine disorder | 22 | [8.6%] | 29 | [18.4%] | 0.003 |
Hypertension | 35 | [13.7%] | 40 | [25.3%] | 0.003 |
Symptoms | |||||
Headache | 231 | [90.2%] | 138 | [87.3%] | 0.36 |
Pulsatile tinnitus | 104 | [40.6%] | 58 | [36.7%] | 0.43 |
Diplopia | 52 | [20.3%] | 27 | [17.1%] | 0.42 |
Transient visual obscurations | 97 | [37.9%] | 66 | [41.8%] | 0.43 |
None | 2 | [0.8%] | 6 | [3.8%] | 0.06 |
Pre-diagnosis duration of symptoms (wk, n=369) | 5.5 | [0–500] | 5.0 | [0–250] | 0.35 |
Follow-up duration (wk, n=376) | 23.5 | [0–368] | 15.0 | [0–279] | 0.09 |
CSF opening pressure (cm CSF, n=339) | 37 | [20–60] | 36 | [20–75] | 0.85 |
Recent weight gain present (self-reported), n=396) | 68 | [26.6%] | 44 | [27.8%] | 0.77 |
Treatment | |||||
Medication** | 239 | [93.4%] | 145 | [91.8%] | 0.54 |
Diet Modification | 102 | [39.8%] | 71 | [44.9%] | 0.31 |
Number of lumbar punctures | 1 | [1–18] | 1 | [1–20] | 0.30 |
CSF Shunt | 65 | [25.4%] | 30 | [19%] | 0.13 |
Optic nerve sheath fenestration | 0.41 | ||||
Unilateral | 15 | [5.9%] | 11 | [7%] | |
Bilateral | 7 | [2.7%] | 8 | [5.1%] |
BMI (body mass index), y (years), CSF (cerebrospinal fluid), wk (weeks)
Contributing medications include vitamin A preparations, minocycline, doxycycline, tetracycline, depot progestins, oral contraceptives, cyclosporine, tacrolimus and recent discontinuation of steroids.
With acetazolamide, furosemide or topiramate