A, B, Summarized input-output plot showing the amplitude of GABAAR-IPSC evoked by a series of stimulation intensities in cortical pyramidal neurons (A) and striatal medium spiny neurons (B) taken from N171-82Q mice (1–2 months old) vs. age-matched wild-type (WT) mice. C–F, Bar graph summary of sIPSC (C, D) and mIPSC (E, F) amplitude and frequency in cortical or striatal neurons taken from WT vs. HD mice (1–2 months old).