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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Trends Biochem Sci. 2012 Feb 1;37(4):144–151. doi: 10.1016/j.tibs.2011.12.003

Figure 2.

Figure 2

ncRNAs that regulate transcription factors. (a) Gas5 ncRNA serves as a mimic of the DNA site to which GR binds. By keeping GR from binding GREs, Gas5 blocks the activation of GR-responsive genes. (b) B2 RNA binds directly to Pol II during the heat shock response. It represses transcription by building into complexes with Pol II at promoters and keeping the polymerase from engaging the DNA as well as blocking phosphorylation of the Pol II CTD by TFIIH. The schematic was adapted with permission from [34]. (c) 7SK RNA, which is found in a complex minimally with P-TEFb, LARP7, and HEXIM1 or HEXIM2, represses the P-TEFb kinase, which is responsible for phosphorylating Ser2 residues in the Pol II CTD during early elongation. (d) lincRNA-p21 recruits hnRNP-K to many p53-responsive genes and mediates repression of these genes. (e) SRA binds many proteins and macromolecular complexes (some of which are shown) to mediate transcriptional regulation. Moreover, through its association with the RNA helicase p68 and CTCF, SRA plays a crucial role in insulating genes from one another throughout the genome.