Table 1.

Serotonin-Positive Case Characteristics

Case No.	Tumor Size (cm)	Ki-67 index (%)a	Mitoses per 10 HPF	Lymph Node Metastases (+/total LNs)	Distant Metastasis	TNM Stage	Serotoninb	Large Duct Involvement	Perineural Invasion	Small Vessel Involvement	Large Vessel Involvement	Necrosis	Major histological architecturec
1	2.2	0	0	0/1	N	T2N0M0	+	N	N	N	N	N	TG
2	4.5	4	0.2d	4/14	Liver	T3N1M1	+	Y	Y	Y	N	N	TG
3	2.5	3	0	2/12	--e	T3N1Mx	++	Y	N	N	N	Y	S
4	2.5	3	0	0/0	--	T2NxMx	++	--f	N	Y	N	N	S
5	1.5	1	0	0/10	--	T3N0Mx	++	N	Y	Y	Y	N	S
6	1.5	1	0	0/25	N	T1N0M0	++	Y	Y	N	N	N	TG
7	3	2	0	0/22	N	T2N0M0	++	Y	Y	Y	N	N	T
8	1.5	1	0	0/16	N	T1N0M0	++	Y	N	N	N	N	S
9	3	16	0.2d	3/27	--	T3N1Mx	++	Y	Y	N	N	Y	S
10	2.4	3	0	0/9	N	T2N0M0	++	Y	N	N	N	N	T
11	1	1	0	0/12	N	T1N0M0	+++	Y	N	N	N	N	S
12	1.5	1	0	0/30	Liver	T1N0M1	+++	Y	Y	N	N	N	T
13	6	2	0	0/17	N	T3N0M0	+++	Y	Y	N	N	N	T
14	2	10	0	1/16	--	T2N1Mx	+++	Y	N	N	N	N	TG

^aMinimum 200 cells counted.

^b+ = <15% positive; ++ = 15–70% positive; +++ = >70% positive.

^cHistological architecture abbreviations: S: Solid; TG: trabecular-glandular; T: trabecular

^d1 mitotic figure in 50 high-power fields counted.

^eInformation on distant metastases unavailable on 5 cases.

^fSlides unavailable