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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Neurochem. 2012 Mar 14;121(3):486–494. doi: 10.1111/j.1471-4159.2012.07699.x

Table 1.

Peptidase activities of the 20S proteasome in EAE (FU/h/μg protein)

Control Young Acute EAE Control Old Chronic EAE
Caspase-like activity 381.3 ± 23.6 498.3 ± 39.2* 328.7 ± 13.9 236.4 ± 29.2 *
Trypsin-like activity 75.7 ± 2.2 108.3 ± 10.9* 62.3 ± 6.5 73.0 ± 7.2
Chymotrypsin-like activity 63.4 ± 4.6 88.3 ± 3.8* 77.2 ± 5.0 49.2 ± 6.1*

Aliquots of cerebellum homogenates from control and EAE mice were used to determine the caspase-like, trypsin-like and chymotrypsin-like proteasomal activity as described in “Materials and Methods”. Values represent the mean ± SEM of 3 animals per experimental group. Asterisks denote values that are significantly different (p<0.05) from control. FU, fluorescence units.