Table 2.
AG129 analytes associated with inflammation or tissue damage undergoing 4-fold or greater change in concentration as a result of 17D-204 infection
| Pro-inflammatory | Serum | Liver | Brain | |
|---|---|---|---|---|
| CD40L | CD40 Ligand | ↑ | ↑ | |
| GMCSF | Granulocyte-Macrophage Colony-Stimulating Factor | ↑ | ||
| KC/GRO | Growth-Regulated Alpha Protein | ↑ | ↑ | |
| IFNγ | Interferon gamma | ↑ | ↑ | ↑ |
| IP-10 | IFNγ Induced Protein 10 | ↑ | ↑ | ↑ |
| IL-1α | Interleukin-1 alpha | ↓ | ↑ | |
| IL-1β | Interleukin-1 beta | ↓ | ||
| Il-2 | Interleukin-2 | ↑ | ↑ | |
| IL-6 | Interleukin-6 | ↑ | ||
| IL-11 | Interleukin-11 | ↑ | ||
| IL-12p70 | Interleukin-12 subunit p70 | ↑ | ||
| MIP-1β | CCL-4/Macrophage Inflammatory Protein-1 beta | ↑ | ↑ | ↑ |
| MIP-1γ | CCL-9/Macrophage Inflammatory Protein-1 gamma | ↑ | ||
| MIP-2 | CXCL-2/Macrophage Inflammatory Protein-2 | ↑ | ||
| MIP-3β | Macrophage Inflammatory Protein-3 beta | ↓ | ||
| MCP-1 | CCL-2/Macrophage Chemotactic Protein-1 | ↑ | ↑ | ↑ |
| MCP-3 | CCL-7/Macrophage Chemotactic Protein-3 | ↑ | ↑ | ↑ |
| MCP-5 | CCL-12/Macrophage Chemotactic Protein-5 | ↑ | ↑ | ↑ |
| OSM | Oncostatin-M | ↑ | ↑ | ↑ |
| RANTES | CCL-5/Regulated upon Activation, Normal T-cell Expressed, and Secreted |
↑ | ↑ | |
| TNFα | Tumor Necrosis Factor alpha | ↑ | ↑ | |
| Anti-inflammatory | ||||
| IL-4 | Interleukin-4 | ↑ | ||
| IL-10 | Interleukin-10 | ↓ | ||
| Tissue Damage | ||||
| Fibrinogen | Fibrinogen | ↓ | ||
| IL-7 | Interleukin-7 | ↑ | ↑ | ↑ |
| MMP-9 | Matrix Metalloproteinase 9 | ↑ | ↑ | |
| Myoglobin | Myoglobin | ↓ | ↑ | |
| MPO | Myeloperoxidase | ↑ | ||
| SGOT | AST/Serum Glutamic Oxaloacetic Transaminase | ↑ | ||
| TPO | Thrombopoietin | ↓ | ||