Table 4.

Comparison of meta-signatures with findings from original study

	Significance Criteria	Down-regulated			Up-regulated
Dataset		Probes	AUC	Overlap	Probes	AUC	Overlap
Stanley AltarC	p < 0.05	848	0.70	14	34	0.78	0
Stanley Bahn	p < 0.05	69	0.85	6	91	0.89	5
Mclean (29)	p < 0.05, intensity > 30	570	0.75	13	300	0.76	7
Mirnics (30)	p < 0.05, |ALR| > 0.58	7	0.55	0	4	0.94	1
Haroutunian (BA10) (31)	p < 0.05, |FC| > 1.4, present calls > 60%	5	0.5	0	14	0.66	1
Haroutunian (BA46) (31)	p < 0.05, |FC| > 1.4, present calls > 60%	50	0.21	0	11	0.59	0
GSE17612 (29)	p < 0.05, intensity > 30	548	0.74	22	466	0.71	7
GSE21138 (52) (Short DOI)	p < 0.05; |FC| > 1.25	482	0.50	1	173	0.57	1
GSE21138 (52) (Int DOI)	p < 0.05; |FC| >1.25	132	0.60	0	78	0.69	0
GSE21138 (52) (Long DOI)	p < 0.05; |FC| > 1.25	37	0.63	1	89	0.63	1

DOI, duration of illness; AUC, area under the curve; FC, fold change

The findings from each dataset are summarized including only probes used in our analysis. The ‘Probes’ column indicates number of probes found from the study based on study specific significance criteria. AUC values were computed from an ROC analysis of each gene set against the corresponding ranked meta-signatures. Overlap values report the number of probes in each gene set that overlaps with probes from the meta-signatures at q < 0.1.