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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Neurobiol Dis. 2012 Feb 4;46(2):325–335. doi: 10.1016/j.nbd.2012.01.013

Figure 1. Prevalence of small-diameter fibers in Twitcher sciatic nerves.

Figure 1

A, B, D, E) Electron micrographs of coronal sections of WT and Twitcher sciatic nerves at P12 and P30 show a decrease in axonal diameter in the Twitcher fibers (A) as compared to age-matched WT fibers (B). Severely demyelinated and abundant small diameter axons were clearly observed in older (P30) Twitcher nerves (D). All images are at the same magnification (bar in A=2 μm). Arrows and asterisk in D point to myelinated axons and edema, respectively. C, F) Distribution profiles based on axonal diameter showed a growing increase in small-caliber axons. A minimum of 50 axons was counted per each nerve (n=3 nerves/time point/genotype). Data were analyzed by ANOVA/post hoc paired test. p<0.05.