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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Neurobiol Dis. 2012 Feb 4;46(2):325–335. doi: 10.1016/j.nbd.2012.01.013

Figure 2. Increased packing of NFs in Twitcher axons.

Figure 2

A–D) High-magnification TEM of coronal sections of P12 and P30 sciatic nerves revealed slightly increased NF density at P12 (A) but significantly higher density at P30 in Twitcher axons (C) as compared to WT axons (B and D, respectively). E,F) High-magnification TEM of longitudinal sections of P30 WT (E) and Twitcher (F) sciatic nerves showed several gaps among NF bundles in the WT nerve. Twitcher NFs were tightly packed together, further confirming the increase in NF density in the mutant axons. (Bar =0.5 microns for A,B and =0.250 microns for C–F).