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. 2012 Mar 1;11(5):922–933. doi: 10.4161/cc.11.5.19421

Figure 3.

Figure 3

MiR-33 specifically targets the 3′UTR of Cdk6 and Ccnd1. (A) Sequence alignment of the human hsa-miR-33 mature sequence with the binding sites of the human Cdk6 3′UTR and (B) human Ccnd1 3′UTR. Luciferase reporter activity in COS-7 cells transfected with CM or miR-33 of the (C) Cdk6 and (D) Ccnd1 3′UTR containing the indicated point mutations (PM) in the miR-33 target sites. Data are expressed as mean % of the 3′UTR activity of control miR ± SEM and are representative of ≥ 3 experiments. *p ≤ 0.05.