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Shelterin proteins stimulate LigI ligase activity on nicked substrates. (A) LigI (0.5 fmol/rxn) activity on non-telomeric nicked substrate (U2•D5•T3) in the absence/presence of increasing concentrations of individual shelterin proteins, pOT1, TRF1 or TRF2, (0, 10, 50, 100 fmol/rxn) and combinations of shelterin proteins (100 fmol/rxn per protein). (B) The same reactions on a telomeric nicked substrate (U3•D7•T2). S, starting substrate; L, ligated product.
