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. 2012 Mar;37(3):92–98. doi: 10.1016/j.tibs.2011.11.003

Figure 3.

Figure 3

TLR4 contains histidine residues that modify its charge distribution upon endosomal acidification. (a) Electrostatic surface potential in the receptor chain of the TLR4-MD-2-LPS crystal structure (PDB code 3FXI) at the dimeric interface. Electropositive surface potentials are represented in blue and electronegative ones in red. (b) The dimerisation site of TLR4 contains five histidine residues that are sensitive to pH changes. (c) Below pH 6.0, histidine protonation may modify the electrostatic surface potential at the dimer interface. (d) The complex might undergo conformational changes upon endosomal acidification.