Figure 5.

Graphical representation of the known connections between the Wnt/β-catenin pathway and the Notch1 signaling pathways, according to the knowledge of the current literature. Additional factors, such as SGK1, are also reported. Sources are represented by previous articles [11,46–49]. Genes with CNAs according to the SNP array analysis (gains or losses) in at least two samples from our series of 15 cortisol-secreting ACAs (frequency, ≥13%) are reported in red with an asterisk. NEXT indicates Notch extracellular domain; NICD, Notch intracellular domain.