Table 2.

Chromosomal Regions with Most Frequent Gains (Minimal Overlapping Regions) Coding for Known Genes Observed in at Least 3/15 Cortisol-Secreting ACAs (Frequency, ≥20%) According to CNAs Detected by SNP Arrays.

Cytoband	Altered Samples	No. Genes	Selected Genes
Already reported regions*
5p15.33	207A, 271A, 802A	28	NKD2, PDCD6
9q34.2-34.3	207A, 271A, 802A	100	COBRA1, EDF1, FBXW5, LHX3, NOTCH1, RXRA, SNAPC4, TRAF2
12q12		1
16q24.3-	207A, 271A, 802A	14	FANCA, MC1R, PRDM7
20p11.1-q11.21	170A, 283A, 802A	3
Newly observed regions
6q16.1	283A, 474A, 802A	1	EPHA7
7p22.3-22.2	207A, 271A, 802A	34	CYP2W1, MAFK, NUDT1, PDGFA, PRKAR1B, UNCX
8q24.3	207A, 271A, 802A	102	ARC, BAI1, SLURP1, ADCK5, CYP11B2, FOXH1, HSF1, LRRC14, MAFA, MAPK15, MFSD3, PUF60, RECQL4
11p15.5	207A, 271A, 802A	74	CD151, CTSD, H19, HRAS, IFITM1, IGF2, INS, INS-IGF2, IRF7, LRDD, PHRF1, RPLP2, SCT
11q11	283A, 350A, 802A	3
Xq28	207A, 271A, 802A	81	DKC1, IRAK1, L1CAM, MECP2

Selected genes: genes considered relevant for tumorigenesis or glucocorticoid production/effects. They include potential oncogenes and tumor suppressor genes, growth or transcription factors, cell differentiation markers, protein kinases (according to the gene set enrichment analysis, see also Table W4), genes involved in steroidogenesis (underlined), or glucocorticoid regulation or in Wnt/β-catenin signaling.

Localization, length, and CN score of the CNAs are reported in Table W3.

^*Regions already reported in previous studies with conventional comparative genomic hybridization [3,12,13].