Fig. 1.

Example cell cycle patterns in HeLa cells. Each image contains DAPI (red) and MPM-2 (green) signal. Representative images are shown of interphase (a), prophase (b), prometaphase (c), metaphase (d), anaphase (e), cytokinesis (f), and telophase (g) in untreated HeLa cells. Treatments that block cells in prometaphase produce differing DAPI staining patterns, whereas MPM-2 staining is consistent: nocodazole (h), paclitaxel (i), ZM447439 (j, k), and monastrol (l). MPM-2, mitotic phosphoprotein monoclonal 2; DAPI, 4′,6-diamidino-2-phenylindole.