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. 2012 Mar 12;109(13):4857-4862. doi: 10.1073/pnas.1118157109

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Fig. 3. — Distribution of fitness effects and correlation with stability. (A–C) Histograms of distributions of fitness effects at 30 °C, 37 °C, and 42 °C for all mutant DHFR strains (16 single and 11 multiple mutants) as measured by competition with a reference WT DHFR strain. Fitness of the reference strain is set to 1. Individual fitness values can be found at Table S2. (D–F) Correlation of fitness values measured for single mutant DHFR strains by competition at 30 °C, 37 °C, and 42 °C to in vitro measured .

Inline graphic — Distribution of fitness effects and correlation with stability. (A–C) Histograms of distributions of fitness effects at 30 °C, 37 °C, and 42 °C for all mutant DHFR strains (16 single and 11 multiple mutants) as measured by competition with a reference WT DHFR strain. Fitness of the reference strain is set to 1. Individual fitness values can be found at Table S2. (D–F) Correlation of fitness values measured for single mutant DHFR strains by competition at 30 °C, 37 °C, and 42 °C to in vitro measured .