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. 2012 Mar 12;109(13):5057–5062. doi: 10.1073/pnas.1120747109

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Fig. 3. — Reduction of the effects of MeHg on the speed of granule cell migration by increasing Ca²⁺ spike frequency through controlling Ca²⁺, cAMP, and IGF1 signaling pathways. (A) Reduction of the recurrence of spontaneous Ca²⁺ spikes in granule cell soma by 10 μM MeHg. (B) Histograms showing a dose-dependent reduction in the frequency of Ca²⁺ spikes in granule cell somata by MeHg. Each column represents the average frequency of Ca²⁺ spikes obtained from at least 50 migrating cells. Bars represent SD. (C and D) Changes in the effects of MeHg (10 μM) on (C) Ca²⁺ spike frequency of granule cells and (D) the speed of migration by caffeine, nicotine, NMDA, Sp-cAMPS, Rp-cAMPS, forskolin, 9CP-Ade, IGF1, IGF1 + PPP, or PPP. In C and D, each column represents the average values obtained from at least 50 migrating cells. Bars represent SD. *P < 0.05 and **P < 0.01 indicate statistical significance.