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. Author manuscript; available in PMC: 2013 Mar 2.
Published in final edited form as: Circ Res. 2012 Feb 2;110(5):669–674. doi: 10.1161/CIRCRESAHA.111.264028

Figure 2. Rem1-265-Cav blocks a small fraction of ICa,L without reducing Contractility.

Figure 2

(A) WT-Rem (MOI of 100) almost completely abolished ICa,L while at equal MOI, Rem1-265-Cav inhibited only a small fraction of the current. Rem1-265 had no effect on ICa,L. Rem1-265-Cav infected myocytes responded normally to Iso. Myocyte contractions (B) and Ca2+ transients (C) were measured 36-48 hours after infection. Rem1-265-Cav had no significant effect on fractional shortening while WT-Rem almost completely abolished contraction. Rem1-265 had no effect. Rem1-265-Cav had no significant effect on Ca2+ transients (n=12-16). *** p<0.001