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Estimated in vitro intrinsic clearance (CLint) of everolimus (a) and tacrolimus (b) metabolism by human recombinant cytochrome P450 (rhCYP) 3A4 and 3A5. Grayed box represents the activity of rhCYP co-expressed with cytochrome b5 and hatched box the activity of rhCYP without cytochrome b5. The CLint were estimated from tacrolimus and everolimus in vitro metabolic half-lives as described in the materials and methods section. Results are derived from duplicate experiments.
