Skip to main content
. Author manuscript; available in PMC: 2012 Apr 11.
Published in final edited form as: Science. 2012 Mar 30;335(6076):1638–1643. doi: 10.1126/science.1215135

Figure 3.

Figure 3

Regulation of glucose homeostasis by mTORC2. A) Glucose tolerance of Alb-Cre RictorLoxP/LoxP mice (* = P< 0.002). B) Pyruvate tolerance of Alb-Cre RictorloxP/loxP mice (* = P < 0.03). C) Effect of rapamycin on glucose tolerance of mice with whole-body deletion of Rictor fasted for 6 hr (* = P < 0.008 for all groups vs. wt). D-I) Glucose infusion rate (D), rate of disappearance of glucose from the circulation (E), hepatic gluconeogenesis (F) and insulin responsiveness (G), and glucose uptake by white adipose tissue (H) and skeletal muscle (I) were determined during a hyperinsulinemic-euglycemic clamp in tamoxifen-treated UbiquitinC-CreERT2 RictorloxP/loxP mice fasted for 6 hr (n = 8 RictorloxP/loxP, 7 UBC-Cre RictorloxP/loxP, ** = P < 0.008; * = P <0.05). All bars indicate mean and SEM.