. Author manuscript; available in PMC: 2012 Apr 11.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Jan;49(1):320–332. doi: 10.1167/iovs.07-0593

Table 1.

Parameter Estimates for the Finalized Model for Retinal Pharmacokinetics of Celecoxib after Periocular Administration in Pigmented BN and Nonpigmented SD Rats

Symbol	Meaning	BN Rats	SD Rats
K10	Elimination rate constant from periocular site	0.135	0.134
K12	Absorption rate constant for cornea	1.5e-4	1.3e-4
K20	Elimination rate constant from the cornea	0.177	0.154
Krel	Dissolution/release rate constant from the formulation	0.024	0.025

Data are expressed as minutes^–1. The structural model is shown in Figure 1E.