Table 2.

Parameter Estimates for Modeling of the Corneal Pharmacokinetics after Subconjunctival Administration of Prednisolone Sodium Succinate in Rabbits

Symbol	Meaning	Value (min–1)
K10	Elimination rate constant from the periocular site	0.072
K12	Absorption rate constant for cornea	2.11e-7
K20	Elimination rate constant from the cornea	0.065

The finalized model (Fig. 1E) for corneal pharmacokinetics of celecoxib after periocular administration in rats was used as the model, and curve fitting was performed to obtain the parameter estimates. Since the drug was administered as a solution, the drug dissolution/release step in the model was not included.