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Hand1 function is not necessary for TH and DBH expression in the SG. A–H, Fluorescent immunohistochemistry upon transverse sections of E11.5 embryos reveals that TH (A–D) and DBH (E–H) protein expression is indistinguishable between control (H1fx/+;H2+/+;Wnt1-Cre(+); A, E) Hand2 heterozygous (H1fx/+;H2+/−;Wnt1-Cre(−); B, F), Hand1 conditionally null (H1fx/−;H2+/+;Wnt1-Cre(+); C, G), and doubly Hand1 conditionally null, Hand2 heterozygous (H1fx/−;H2+/−;Wnt1-Cre(+); A, E) mutants.
