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Summary of ionotropic glutamate receptor editing sites and their effects.
| Receptor | Subunit | Site | Editing | Consequence |
|---|---|---|---|---|
| AMPA | GluA2 | Q/R site M2 | A→I | ↓Ca2+-permeability |
| ↓Conductance | ||||
| ↓Spermine block | ||||
| ↓Blockade by toxins | ||||
| GluA2,3,4 | R/G site between M3 and M4 | A→I | ↑Recovery from desensitization | |
| Kainate | GluK1,2 | Q/R site M2 | A→I | ↓Ca2+-permeability |
| ↓Conductance | ||||
| ↓Spermine block | ||||
| ↓Blockade by toxins | ||||
| GluK2 | I/V site M1 | A→I | ↓Ca2+-permeability | |
| Y/C site M1 |
