Table 3.

Relationship Between Metabolite Factor Levels and Adverse Events

Factor	Name	Factor Levels – No Event Subjects (N=352)	Factor Levels – Event Subjects (N=126)	Hazard Ratio [95% Confidence Interval]	P*
1	Medium-Chain Acylcarnitines	−0.02 ± 1.1	0.06 ± 0.74	1.07 [0.94-1.23]	0.30
2	Short Chain Dicarboxyl- acylcarnitines	−0.09 ± 0.85	0.24 ± 1.3	1.19 [1.07-1.33]	0.001
3	Long-Chain Dicarboxyl- acylcarnitines	−0.04 ± 0.81	0.12 ± 1.39	1.11 [0.99-1.24]	0.08
4	Long Chain Acylcarnitines	0.03 ± 1.00	−0.09 ± 0.99	0.90 [0.75-1.08]	0.25
5	Ketone-Related	−0.07 ± 0.92	0.19 ± 1.17	1.21 [1.04-1.41]	0.02
6	Short-Chain Acylcarnitines	−0.07 ± 0.71	0.19 ± 1.52	1.20 [1.06-1.35]	0.004
7	Branched-Chain Amino Acids	−0.01 ± 0.98	0.03 ± 1.06	1.02 [0.85-1.21]	0.87
8	Urea Cycle Amino Acids	0.03 ± 0.97	−0.09 ± 1.08	0.91 [0.72-1.13]	0.39
9	Amino Acids	−0.001 ± 1.01	0.002 ± 0.98	1.15 [0.96-1.38]	0.13
10	Various	−0.04 ± 0.99	0.10 ± 1.03	1.02 [0.86-1.20]	0.86
11	Medium-Chain Acylcarnitines	−0.05 ± 0.95	0.14 ± 1.12	1.16 [0.99-1.37]	0.07
12	Various	−0.02 ± 0.98	0.05 ± 1.05	1.07 [0.90-1.27]	0.48

Metabolite factors significantly associated with time-to-event are highlighted in bold.

^*P-value for univariate Cox proportional hazards regression model of association of factor level with time-to-event.