Table 2.
Treatment outcome by groups of early response to treatment measured at day 8.
| Good responder (N = 133) | Poor responder (n = 32) | Total (N = 165) | OR | 95% CI | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | ||||
| Induction treatment | |||||||||
| Complete remission | 102 | 76.7 | 15 | 46.9 | 117 | 70.9 | |||
| Induction failures | 31 | 23.3 | 17 | 53.1 | 48 | 29.1 | 3.73a | 1.67–8.32 | 0.0011 |
| Abandonment | 14 | 10.5 | 6 | 18.8 | 20 | 12.1 | 2.91a | 0.97–8.75 | 0.092 |
| Death | 11 | 8.3 | 6 | 18.8 | 17 | 10.3 | 3.71a | 1.19–11.51 | 0.032 |
| Resistant disease | 6 | 4.5 | 5 | 15.6 | 11 | 6.7 | 5.67a | 1.54–20.89 | 0.012 |
|
| |||||||||
| Adverse event after CR | |||||||||
| Continuous CR | 33 | 32.4 | 3 | 20.0 | 36 | 30.8 | |||
| Relapse | 38 | 37.3 | 7 | 46.7 | 45 | 38.5 | 2.02b | 0.48–8.47 | 0.502 |
| Death | 16 | 15.7 | 3 | 20.0 | 19 | 16.2 | 2.06b | 0.37–11.38 | 0.402 |
| Abandonment | 15 | 14.7 | 2 | 13.3 | 17 | 14.5 | 1.47b | 0.22–9.71 | 0.652 |
|
| |||||||||
| Site of relapse | 38 | 7 | |||||||
| Isolated hematological | 28 | 73.7 | 5 | 71.4 | 33 | 73.4 | |||
| Isolated CNS | 7 | 18.5 | 1 | 14.3 | 8 | 17.8 | |||
| Other | 3 | 7.8 | 1 | 14.3 | 4 | 9.8 | |||
OR: odds ratio for poor responders relative to good responders; CI: confidence interval; CR: complete remission. aORs for any induction failure and specific induction failures (CR during induction is taken as the reference outcome category). bORs for first event after CR (continuous CR is taken as the reference outcome category). 1Chi-square test. 2Fisher exact test.