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. 2011 Aug 19;17(11-12):1295–1305. doi: 10.2119/molmed.2011.00131

Figure 8.

Figure 8

CAN attenuated collagen deposition in rat UUO kidney. The left kidneys of male Wistar rats were subjected to UUO as described in Materials and Methods. Oral gavage with CAN (2.5 mg/kg, twice a day) was delivered from day 1 to day 14 of UUO. At 14 d after UUO, the kidneys were harvested and cut into 6-μm-thick slices for Masson trichrome staining. (A) Sham-operative kidneys showed no positive Masson trichrome staining. Progressive tubular dilation, interstitial volume expansion and development of fibrosis were observed after 14 d of UUO (B), and CAN significantly attenuated UUO-induced interstitial damages and fibrosis (C). (D) CAN-treated sham operative did not show the interstitial damages and fibrosis. (E) The degree of interstitial collagen deposits in Masson trichrome–stained sections of the kidney tissue graded semiquantitatively as described in Materials and Methods were averaged for rats of each group (n = 3 for each group). G indicates glomerulus and T is renal tubule. *P < 0.05 versus the sham operation (Sham) group. #P < 0.05 versus the UUO group.