Table 4.
Relative risk of selected fractures among patients with MGUS (vs matched controls), stratified by M protein concentration at diagnosis
| Disease/grouping | Concentration of M protein below 10 g/L |
Concentration of M protein above 10 g/L |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-y follow-up |
10-y follow-up |
5-y follow-up |
10-y follow-up |
|||||||||
| MGUS (n = 1732) | Ctrl (n = 6585) | HR* (95% CI) | MGUS | Ctrl | HR* (95% CI) | MGUS (n = 1108) | Ctrl (n = 4214) | HR* (95% CI) | MGUS | Ctrl | HR* (95% CI) | |
| Any fracture | 173 | 448 | 1.61 (1.35-1.92) | 278 | 776 | 1.52 (1.32-1.74) | 117 | 303 | 1.55 (1.25-1.92) | 184 | 497 | 1.52 (1.28-1.80) |
| Axial fractures† | 64 | 113 | 2.28 (1.68-3.11) | 100 | 211 | 1.99 (1.57-2.53) | 43 | 88 | 1.86 (1.29-2.69) | 68 | 134 | 2.02 (1.51-2.70) |
| Distal fractures‡ | 123 | 360 | 1.41 (1.15-1.74) | 202 | 637 | 1.32 (1.13-1.55) | 71 | 225 | 1.26 (0.97-1.65) | 119 | 393 | 1.22 (1.00-1.50) |
HR indicates hazard ratio; CI, confidence interval; and ctrl, controls.
*
Adjusted for age, sex, and calendar period.
†
Skull, vertebral/pelvis, sternum/costae.
‡
Arm.