Figure 2. Delineation of the APP duplicated region identified here and those in previous studies.

Approximate locations of the duplicated intervals across studies are shown. Solid arrows indicate minimal size of the duplicated interval; dotted lines indicate maximal boundaries. Note that our study is the only to use high-density genome-wide association study data, allowing a much more precise delineation of the duplicated interval than the lower-resolution microsatellite-based mapping. Physical location of duplicated segments from microarray data mapped to hg18 assembly are family (Fam.) VI (chr21: 23984747–27466529) and family BRB (chr21: 26125668–26505191).