Table 1.

Genetic association results of 2 APP promoter polymorphisms previously associated with AD risk^a

Abbreviations: AD = Alzheimer disease; APP = amyloid precursor protein; CAG = Consortium on Alzheimer's Genetics; NCRAD = National Cell Repository for Alzheimer's Disease; NIA = National Institute on Aging; NIMH = National Institute of Mental Health; SNP = single nucleotide polymorphism.

^ap Value represents p values calculated using PBAT with additive model and affection status, restricted to Caucasian-only families (negative p values indicate undertransmission to affected family members). Fams represents the number of informative families. Combined represents meta-analysis of results across all 4 samples using METAL. See table e-2 for meta-analysis results on 421 genotyped and imputed SNPs in the APP region determined in the NIMH and NCRAD samples.