Table 1.
Gene products whose silencing resulted in greater than 50% cell death in the presence of 90 μM imexon (IC10)
| Gene Symbol | Gene Name | siRNA (% survival) | siRNA+imexon (% survival) | Ratio siRNA +imexon siRNA |
|---|---|---|---|---|
| EIF2B5 | Eukaryotic translation initiation factor 2B, subunit 5 | 78.2 | 27.7 | 35.4 |
| SLC9A3R2 | Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 53.7 | 19.4 | 36.0 |
| ARHGAP26 | Rho GTPase activating protein 26 | 73.1 | 31.0 | 42.5 |
| SERPINC1 | serpin peptidase inhibitor, clade C, member 1 | 85.9 | 36.6 | 42.6 |
| OR2AE1 | olfactory receptor, family 2, subfamily AE, member 1 | 101.7 | 43.4 | 42.7 |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 | 89.2 | 38.8 | 43.8 |
| KDR | kinase insert domain receptor | 87.5 | 38.1 | 43.5 |
| SERPINE1 | serpin peptidase inhibitor, clade E, member 1 | 66.1 | 28.8 | 43.5 |
| SET | SET nuclear oncogene | 82.4 | 36.2 | 43.9 |
| OR1L1 | olfactory receptor, family 1, subfamily L, member 1 | 105.7 | 47.2 | 44.7 |
| SERPINE2 | serpin peptidase inhibitor, clade E, member 2 | 55.1 | 25.2 | 45.7 |
| FBX08 | F-box protein 8 | 65.4 | 30.1 | 46.0 |
| ZNF200 | zinc finger protein 200 | 102.2 | 47.2 | 46.2 |
| SP7 | Sp7 transcription factor | 36.5 | 17.0 | 46.7 |
| ZFP36L1 | zinc finger protein 36, C3H type-like 1 | 76.8 | 36.0 | 46.9 |
| OR51G2 | olfactory receptor, family 51, subfamily G, member 2 | 85.1 | 40.4 | 47.5 |
| WASH1 | WAS protein family homolog 1 | 90.7 | 43.7 | 48.2 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 60.0 | 29.4 | 49.0 |
| CYTH1 | cytohesin 1 | 55.1 | 27.3 | 49.6 |
| MRLP10 | mitochondrial ribosomal protein L10 | 65.4 | 32.5 | 49.8 |