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Concept of cell delivery carriers for antisense oligomers based on delivery ligands such as cell penetrating peptide (CPP) conjugated to peptide nucleic acids (PNAs). (A) The carrier CPP-PNA is hybridized in an anti-parallel orientation to (part of) the target (antisense) cargo oligomer. (B) Design of carrier PNAs with different length (6–9 nucleobases for both cPNA 1 and cPNA 2 and 8 or 10 or 8 nucleobases for cPNA3) and different target positions within the antisense PNA.
