Table 3. Fold changes in selected gene expression determined by qPCR for WNV-infected primary hRPE versus ARPE-19 cells.
| Gene | ARPE19 | hRPE1 | hRPE2 | hRPE3 | hRPE4 |
|---|---|---|---|---|---|
|
TNFRS10D |
5.404 |
0.16 |
0.16 |
0.292 |
0.209 |
|
CFB |
3.334 |
16.225 |
15.199 |
6.038 |
39.097 |
| BAMBI | 2.316 | 290.042 | 13.641 | 10.797 | 187.345 |
Genes with the most dissimilar fold changes between ARPE-19 and the primary retinal pigment epithelium (RPE) cell groups are shown. TNFRS10D is the most dissimilar, being upregulated in ARPE-19 cells, compared to all other primary RPE groups, which were downregulated. Both CFB and BAMBI showed differences only in the magnitude of upregulation between ARPE-19 and primary RPE groups. Abbreviations: TNFRSF10D: tumor necrosis factor receptor superfamily, member 10d; CFB: complement factor B; BAMBI: BMP and activin membrane-bound inhibitor homolog.