Table 7. Haplotype analysis of IGF-1 in extreme myopia and control subjects.
| Block | Haplotype | Freq of case (%) | Freq of control (%) | p value* | OR (95%CI) | P-permutation** |
|---|---|---|---|---|---|---|
|
Block 1 | ||||||
| (rs10860862-rs6214) |
GG |
46.5 |
49.7 |
0.232 |
1 |
0.7773 |
| |
GA |
37.0 |
32.7 |
0.098 |
1.209 (0.956–1.529) |
0.4638 |
| |
TA |
16.5 |
17.4 |
0.661 |
1.014 (0.752–1.367) |
0.9977 |
|
Block 2 | ||||||
| (rs5742629-rs12423791) |
AG |
56.5 |
62.3 |
0.026 |
1 |
0.1541 |
| |
GC |
29.6 |
22.9 |
0.005 |
1.426 (1.114–1.827) |
0.0334 |
| |
GG |
13.9 |
14.7 |
0.670 |
1.044 (0.764–1.426) |
0.9981 |
|
Block 3 | ||||||
| (rs35766-rs1457601) |
GA |
66.1 |
71.1 |
0.042 |
1 |
0.2409 |
| |
AT |
27.5 |
22.6 |
0.037 |
1.308 (1.002–1.673) |
0.2138 |
| AA | 6.5 | 6.2 | 0.875 | 1.112 (0.718–1.723) | 1.0000 | |
The asterisk indicates that differences in the estimated haplotype frequency were examined by the χ2 test. The double asterisk indicates that 50,000 permutations were performed. OR indicates odds ratio and CI indicates confidence interval which were performed by a logistic regression model.