Table 2. Summary of allelic odds ratios of gene variants in polypoidal choroidal vasculopathy.
| Gene/locus | SNP | Allele | PCV versus control OR (95% CI) | Case | Control | N | Ref | PCV versus AMD OR (95% CI) | N | Ref |
|---|---|---|---|---|---|---|---|---|---|---|
| LOC387715 |
rs10490924 |
T |
2.27 (1.84–2.79) |
2742 |
5383 |
9 |
Figure 2A |
0.66 (0.57–0.76) |
5 |
Figure 3A |
| HTRA1 |
rs11200638 |
A |
2.72 (2.04–3.63) |
864 |
1150 |
4 |
Figure 2B |
0.86 (0.64–1.16) |
2 |
Figure 3B |
| CFH |
rs1061170 |
C |
1.72 (1.42–2.10) |
1534 |
3950 |
4 |
Figure 2C |
0.91 (0.71–1.18) |
2 |
Figure 3C |
| CFH |
rs800292 |
G |
2.10 (1.87–2.37) |
2190 |
4138 |
5 |
Figure 2D |
0.95 (0.79–1.16) |
2 |
Figure 3D |
| CFH |
rs3753394 |
T |
2.12 (1.61–2.77) |
404 |
532 |
2 |
Figure 2E |
NA |
|
|
| CFH |
rs1329428 |
T |
1.74 (1.33–2.28) |
404 |
532 |
2 |
Figure 2F |
NA |
|
|
| CFH |
rs1410996 |
C |
1.82 (1.39–2.37) |
370 |
1082 |
2 |
Figure 2G |
0.71 (0.47–1.06) |
1 |
[22] |
| CFB |
rs415667 |
A |
0.79 (0.40–1.57) |
526 |
1288 |
3 |
Figure 2H |
1.35 (0.38–4.73) |
1 |
[22] |
| C2 |
rs547154 |
T |
0.56 (0.36–0.87) |
526 |
1288 |
3 |
Figure 2I |
0.73 (0.26–2.10) |
1 |
[22] |
| SERPING1 |
rs2511989 |
A |
0.97 (0.76–1.24) |
1256 |
898 |
2 |
Figure 2J |
0.91 (0.70–1.20) |
1 |
[37] |
| Elastin |
rs2301995 |
G |
1.17 (0.97–1.41) |
1644 |
1886 |
4 |
Figure 2K |
1.07 (0.68–1.70) |
4 |
Figure 3E |
| PEDF |
rs1136287 |
T |
0.99 (0.80–1.22) |
634 |
742 |
2 |
Figure 2L |
1.07 (0.72–1.61) |
2 |
Figure 3F |
| SOD2 |
rs4880 |
C |
0.81 (0.52–1.26) |
140 |
189 |
1 |
[40] |
1.11 (0.66–1.88) |
1 |
[40] |
| TLR3 |
rs3775291 |
T |
1.27 (0.93–1.73) |
120 |
274 |
1 |
[41] |
1.16 (0.81–1.66) |
1 |
[41] |
| 9p21 |
rs10757278 |
A |
1.44 (1.08–1.94) |
177 |
182 |
1 |
[42] |
1.12 (0.81–1.54) |
1 |
[42] |
| RDBP |
rs3880457 |
C |
0.31 (0.13–0.71) |
136 |
183 |
1 |
[21] |
NA |
|
|
| SKIV2L |
rs2075702 |
C |
0.31 (0.13–0.71) |
136 |
183 |
1 |
[21] |
NA |
|
|
| C3 | rs2241394 | C | 3.47 (1.48–8.38) | 100 | 190 | 1 | [29] | NA |
SNP: single nucleotide polymorphism; PCV: polypoidal choroidal vasculopathy; AMD: age-related macular degeneration; OR: odds ratio; CI: confidence interval; NA: not available. N: number of study cohorts. Ref: reference.