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. 2012 Apr 11;7(4):e35083. doi: 10.1371/journal.pone.0035083

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Lai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Antiserum was used to compete with Eu-labeled mAbs specific for different antigenic domains of Env. The fluorescent signal of Europium is proportional to residual mAb binding, relative to the prebleed controls. A decrease in residual mAb binding indicated an increase in specificity of the antiserum for the epitope site. Both the FCA/FIA (groups 1&2) and the combination of Carbopol-971P and MF59 (group 10) displayed potent activities towards both CD4bs and CD4i and modest activities towards the V3 loop and MPER. By contrast, antisera from animals vaccinated with other adjuvants displayed only modest activities to CD4bs and CD4i and little, if any, towards V3 and MPER.