Table 4. Genetic association between iron and ferritin levels and SNPs in SLC11A2 and TMPRSS6 in SAPHIR.

	Iron [µg/dl]						Ferritin [µg/l]
SNP	AA	Aa	aa	β	95% CI	p-value	AA	Aa	aa	β	95% CI	p-value
rs6580779 (SLC11A2)	100.23	98.82	97.41	−1.41	(−6.11–3.29)	0.567	175.30	166.62	157.94	−8.68	(−35.03–17.67)	0.108
rs161044 (SLC11A2)	100.23	98.57	96.90	−1.67	(−6.34–3.01)	0.506	175.77	167.09	158.40	−8.68	(−34.86–17.50)	0.102
rs150909 (SLC11A2)	100.25	98.57	96.89	−1.68	(−6.36–2.99)	0.503	175.51	167.02	158.53	−8.48	(−34.66–17.69)	0.107
rs149411 (SLC11A2)	100.76	99.84	98.93	−0.91	(−3.19–1.37)	0.564	175.80	174.55	173.29	−1.25	(−14.07–11.56)	0.534
rs11704654 (TMPRSS6)	100.44	99.40	98.37	−1.03	(−3.83–1.78)	0.675	173.97	175.99	178.01	2.02	(−13.65–17.70)	0.569
rs4820268 (TMPRSS6)	104.61	99.58	94.54	−5.03	(−7.24–−2.82)	3.9E-6	191.17	172.98	154.78	−18.19	(−30.62–−5.75)	0.001
rs855791 (TMPRSS6)	104.60	99.41	94.22	−5.19	(−7.40–−2.96)	2.0E-6	187.97	171.86	155.75	−16.10	(−28.60–−3.61)	0.002

Note: For linear regression, an additive genetic effect of the SNPs on the outcome variable was assumed; linear regression analyses were adjusted for age and gender. The p-values were based on the log-transformed model, and the β-estimates were based on the model on the original scale.