Table III.
Association of three SNPs and breast cancer risk across studies
| SNP (ref/risk allele) | Study | Risk allele frequency |
Per-allele OR (95% CI)a | |
| Case | Control | |||
| rs2981578 (A/G) | Nigeria | 0.951 | 0.935 | 1.35 (0.88–2.05) |
| Barbados | 0.919 | 0.920 | 1.00 (0.53–1.87) | |
| Baltimore | 0.893 | 0.832 | 1.62 (0.93–2.83) | |
| Pennsylvania | 0.820 | 0.843 | 0.88 (0.60–1.28) | |
| Chicago | 0.872 | 0.837 | 1.44 (1.01–2.05) | |
| Northern California | 0.854 | 0.828 | 1.24 (0.85–1.82) | |
| P for heterogeneity | 0.34 | |||
| rs3104793 (T/C) | Nigeria | 0.664 | 0.622 | 1.20 (0.98–1.47) |
| Barbados | 0.591 | 0.602 | 0.95 (0.67–1.35) | |
| Baltimore | 0.625 | 0.595 | 1.13 (0.77–1.65) | |
| Pennsylvania | 0.573 | 0.568 | 1.03 (0.78–1.38) | |
| Chicago | 0.584 | 0.554 | 1.16 (0.91–1.48) | |
| Northern California | 0.601 | 0.568 | 1.14 (0.87–1.51) | |
| P for heterogeneity | 0.89 | |||
| rs9397435 (A/G) | Nigeria | 0.088 | 0.067 | 1.34 (0.92–1.96) |
| Barbados | 0.086 | 0.086 | 1.00 (0.55–1.83) | |
| Baltimore | 0.085 | 0.059 | 1.47 (0.71–3.04) | |
| Pennsylvania | 0.099 | 0.081 | 1.27 (0.78–2.06) | |
| Chicago | 0.091 | 0.073 | 1.29 (0.83–2.01) | |
| Northern California | 0.118 | 0.073 | 1.71 (1.06–2.74) | |
| P for heterogeneity | 0.48 | |||
a
OR (95% CI) from logistic regressions adjusted for African ancestry.