Table 3. Genes that were induced only in aortic or femoral plaques compared to non-atherosclerotic internal thoracic arteries analyzed with genome-wide expression array (GWEA).
Gene (ID) | Gene ID | Fold change | Function |
Aortic plaques | |||
CHGA, chromogranin A | 1113 | 5.8 | Secretory granules formation, immunity against microbes [66], cancer [67], hypertension and myocardial infarction [38], [68] |
CSF3, colony stimulating factor 3 | 1440 | 4.6 | Survival/proliferation of neutrophils and macrophages [69], arteriogenesis [70] |
GAGE12I, G antigen 12I | 26748 | 4.5 | Antigen, anti-apoptotic factor [71], [72] |
C4orf7, choromosome 4 open reading frame 7 | 260436 | 4.3 | B cell immunity, tumorigenesis [73] |
GAGE6, G antigen 6 | 2578 | 4.0 | Antigen, cancer [74] |
LTF, lactotransferrin | 4057 | 3.7 | Immune modulator [15] |
PRPH, peripherin | 5630 | 3.6 | Intermediate filament [75] |
MS4A1, membrane-spanning 4-domains | 931 | 3.5 | B cell immunity [76], [77], cancer [78] |
Femoral plaques | |||
C1QTNF3, C1q and tumor necrosis factor related protein 3 | 114899 | 3.4 | Adipose tissue secreted protein, anti-inflammatory [79] |
CHAD, chondroadherin | 1101 | 3.9 | Extracellular matrix structure modification [42], [80] |
PTN, pleiotrophin | 5764 | 4.7 | Cell differentiation [48], angiogenesis [47], cancer [81] |
For all genes, the p-value was less than 0.05.