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. 2012 Apr 11;7(4):e33787. doi: 10.1371/journal.pone.0033787

Table 3. Genes that were induced only in aortic or femoral plaques compared to non-atherosclerotic internal thoracic arteries analyzed with genome-wide expression array (GWEA).

Gene (ID) Gene ID Fold change Function
Aortic plaques
CHGA, chromogranin A 1113 5.8 Secretory granules formation, immunity against microbes [66], cancer [67], hypertension and myocardial infarction [38], [68]
CSF3, colony stimulating factor 3 1440 4.6 Survival/proliferation of neutrophils and macrophages [69], arteriogenesis [70]
GAGE12I, G antigen 12I 26748 4.5 Antigen, anti-apoptotic factor [71], [72]
C4orf7, choromosome 4 open reading frame 7 260436 4.3 B cell immunity, tumorigenesis [73]
GAGE6, G antigen 6 2578 4.0 Antigen, cancer [74]
LTF, lactotransferrin 4057 3.7 Immune modulator [15]
PRPH, peripherin 5630 3.6 Intermediate filament [75]
MS4A1, membrane-spanning 4-domains 931 3.5 B cell immunity [76], [77], cancer [78]
Femoral plaques
C1QTNF3, C1q and tumor necrosis factor related protein 3 114899 3.4 Adipose tissue secreted protein, anti-inflammatory [79]
CHAD, chondroadherin 1101 3.9 Extracellular matrix structure modification [42], [80]
PTN, pleiotrophin 5764 4.7 Cell differentiation [48], angiogenesis [47], cancer [81]

For all genes, the p-value was less than 0.05.