Figure 2. Time course of changes in sFlt1 (A), PlGF (B), VEGF₁₆₅ (C) and sEng (D) with UFH and bivalirudin at baseline and 1, 6 and 24 hours after administration of anticoagulant.

Note that levels of all angiogenic peptides revert to baseline levels by 24 hours with UFH and levels do not change significantly over 24 hours with bivalirudin.