Table 4.
Mean of mediator levels measured in plasma, muscle and synovial fluid in cases and controls
| Mediators | Painful TMJD Cases (n = 23) | Pain-free Controls (n = 27) | P-value |
|---|---|---|---|
| Mean (95%CI) | Mean (95%CI) | ||
| NGF plasma (pg/ml) | 42.8 (32.2-53.4) | 57.0 (48.5-65.4) | 0.043 |
| NGF muscle1 | 5.9 (5.7-6.1) | 6.0 (5.8-6.1) | 0.57 |
| NGF synovial2 | 30.1 (26.6-33.5) | 26.7 (23.7-29.7) | 0.15 |
| BK plasma2 | 9.0 (8.0-10.1) | 10.0 (9.2-10.9) | 0.14 |
| BK muscle (fg/ml) | 205.8 (172.8-238.7) | 221.5 (191.3-251.8) | 0.48 |
| BK synovial1 | 4.3 (4.0-4.7) | 4.5 (4.2-4.8) | 0.51 |
| PGE2 plasma1 | 4.3 (3.8-4.7) | 4.6 (4.2-5.0) | 0.30 |
| PGE2 muscle1 | 6.2 (6.1-6.4) | 6.3 (6.2-6.4) | 0.32 |
| PGE2 synovial1 | 4.4 (4.0-4.8) | 4.6 (4.3-5.0) | 0.40 |
| LTB4 plasma2 | 17.3 (15.1-19.5) | 16.9 (15.0-18.7) | 0.77 |
| LTB4 muscle (fg/ml) | 157.7 (126.8-188.6) | 170.9 (144.1-197.6) | 0.52 |
| LTB4 synovial (pg/ml) | 118.3 (94.6-142.0) | 121.3 (101.5-141.1) | 0.85 |
| F2I plasma2 | 8.8 (7.8-9.9) | 8.7 (7.7-9.7) | 0.90 |
| F2I muscle (fg/ml) | 202.5 (173.5-231.6) | 247.5 (219.8-275.3) | 0.034 |
| F2I synovial (pg/ml) | 91.7 (65.2-118.2) | 118.6 (96.2-141.0) | 0.13 |
| SP plasma (pg/ml) | 20.4 (16.3-24.6) | 22.4 (18.5-26.5) | 0.48 |
| SP muscle (fg/ml) | 488.0 (398.0-578.1) | 549.2(472.8-625.7) | 0.30 |
| SP synovial1 | 4.4 (4.1-4.6) | 4.4 (4.2-4.7) | 0.88 |
Note:
1
Logarithmic transformation
2
Box Cox transformation. Units not shown when transformations were performed on data.
3
Plasma NGF P = 0.04 > alpha level of 0.0056 based on the false discovery rate; and muscle
4
F2I P = 0.03 > alpha level of 0.0028 based on the false discovery rate.