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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Appl Microbiol. 2012 Mar 20;112(5):1020–1033. doi: 10.1111/j.1365-2672.2012.05270.x

Table 2.

Altered expression of genes associated with cell lysis in CPV treated S. aureus COL cells

Locus ID Genea Gene/Protein Name Sub-functional Category Fold Change
Cell envelope
Downregulated Genes
SACOL0938 dltD DltD protein Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −10.41
SACOL0054 NA Mur ligase family protein, authentic frameshift Biosynthesis and degradation of murein sacculus and peptidoglycan −9.61
SACOL0937 dltC D-alanyl carrier protein Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −5.99
SACOL0936 dltB DltB protein −5.41
SACOL0247 lrgA holin-like protein LrgA Biosynthesis and degradation of murein sacculus and peptidoglycan −4.64
SACOL0052 NA glycosyl transferase, group 1 family protein Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −4.19
SACOL1195 mraY phospho-N-acetylmuramoyl-pentapeptide-transferase Biosynthesis and degradation of murein sacculus and peptidoglycan −3.71
SACOL0697 tagX teichoic acid biosynthesis protein X −3.51
SACOL0801 murB UDP-N-acetylenolpyruvoylglucosamine reductase −2.97
SACOL1023 murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase −2.89
SACOL1194 pbp1 penicillin-binding protein 1 −2.5
SACOL1196 murD UDP-N-acetylmuramoylalanine--D-glutamate ligase −2.45
SACOL2074 NA D-alanine--D-alanine ligase −2.39
SACOL1687 NA N-acetylmuramoyl-L-alanine amidase, family 3 Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −2.38
SACOL0543 glmU UDP-N-acetylglucosamine pyrophosphorylase −2.21
SACOL2103 NA UDP-N-acetylglucosamine 2-epimerase −2.21
SACOL0033 mecA penicillin-binding protein 2 Biosynthesis and degradation of murein sacculus and peptidoglycan −2.15
SACOL1329 femC glutamine synthetase FemC −2.15
SACOL0242 NA teichoic acid biosynthesis protein, putative −2.12
SACOL1134 kdtB lipopolysaccharide core biosynthesis protein KdtB Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −2.09
SACOL1609 pbp3 penicillin-binding protein 3 Biosynthesis and degradation of murein sacculus and peptidoglycan −2.01
SACOL1453 murG UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase −1.98
SACOL0263 lytM peptidoglycan hydrolase −1.96
SACOL0695 NA tagG protein, teichoic acid ABC transporter protein, putative −1.87
SACOL1066 NA fmt protein −1.83
SACOL1062 atl bifunctional autolysin Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides −1.78
SACOL1424 NA phosphate ABC transporter, phosphate-binding protein Other −1.74
SACOL1790 murC UDP-N-acetylmuramate--alanine ligase Biosynthesis and degradation of murein sacculus and peptidoglycan −1.58
SACOL1951 NA Mur ligase family protein −1.57
Upregulated Genes
SACOL2571 cwrA conserved hypothetical protein Conserved 24.05
SACOL1434 NA alanine racemase family protein Biosynthesis and degradation of murein sacculus and peptidoglycan 21.26
SACOL0147 cap5L capsular polysaccharide biosynthesis protein Cap5L Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 4.22
SACOL0150 cap5O capsular polysaccharide biosynthesis protein Cap5O 4.02
SACOL0148 cap5M capsular polysaccharide biosynthesis galactosyltransferase Cap5M 3.98
SACOL0151 cap5P UDP-N-acetylglucosamine 2-epimerase Cap5P 3.61
SACOL0149 cap5N capsular polysaccharide biosynthesis protein Cap5N 3.55
SACOL1161 murI glutamate racemase Biosynthesis and degradation of murein sacculus and peptidoglycan 3.11
SACOL0146 cap5K capsular polysaccharide biosynthesis protein Cap5K Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 2.95
SACOL0144 cap5I capsular polysaccharide biosynthesis protein Cap5I 2.83
SACOL0145 cap5J capsular polysaccharide biosynthesis protein Cap5J 2.79
SACOL0140 cap5E capsular polysaccharide biosynthesis protein Cap5E 2.67
SACOL0141 cap5F capsular polysaccharide biosynthesis protein Cap5F 2.17
SACOL2092 murAA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 Biosynthesis and degradation of murein sacculus and peptidoglycan 2.1
SACOL0143 cap5H capsular polysaccharide biosynthesis protein Cap5H Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 2.04
SACOL0699 pbp4 penicillin-binding protein 4 Biosynthesis and degradation of murein sacculus and peptidoglycan 2.04
SACOL0142 cap5G UDP-N-acetylglucosamine 2-epimerase Cap5G Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 1.99
SACOL0136 cap5A capsular polysaccharide biosynthesis protein Cap5A 1.68
SACOL0137 cap5B capsular polysaccharide biosynthesis protein Cap5B 1.67
SACOL2116 murAB UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 Biosynthesis and degradation of murein sacculus and peptidoglycan 1.67
Cellular processes
Downregulated Genes
SACOL0935 dltA D-alanine-activating enzyme/D-alanine-D-alanyl carrier protein ligase Toxin production and resistance −11.93
SACOL2295 NA staphyloxanthin biosynthesis protein, putative Pathogenesis −8.55
SACOL1535 srrA DNA-binding response regulator SrrA −8
SACOL0244 scdA ScdA protein Cell division −6.24
SACOL0270 NA staphyloxanthin biosynthesis protein, putative Pathogenesis −5.55
SACOL0095 spa immunoglobulin G binding protein A precursor −5.54
SACOL1437 NA cold shock protein, CSD family Adaptations to atypical conditions −4.87
SACOL2126 luxS autoinducer-2 production protein LuxS Other −4.15
SACOL0956 kapB kinase-associated protein B Adaptations to atypical conditions −3.8
SACOL1193 NA cell division protein FtsL Cell division −3.6
SACOL0608 sdrC sdrC protein Cell adhesion −3.53
SACOL1328 glnR glutamine synthetase repressor Toxin production and resistance −3.35
SACOL2291 NA staphyloxanthin biosynthesis protein Pathogenesis −3.33
SACOL0552 NA general stress protein 13 Adaptations to atypical conditions −3.32
SACOL1534 srrB sensor histidine kinase SrrB Pathogenesis −3.27
SACOL0743 bacA bacitracin resistance protein Toxin production and resistance −3.23
SACOL1396 fmtC fmtC protein −3.18
SACOL2075 ftsW cell division protein, FtsW/RodA/SpoVE family Cell division −3.12
SACOL1197 divIB cell division protein −2.91
SACOL0766 saeR DNA-binding response regulator SaeR Pathogenesis −2.87
SACOL1205 NA cell-division initiation protein, putative Cell division −2.86
SACOL0452 ahpC alkyl hydroperoxide reductase, C subunit Detoxification −2.8
SACOL1537 scpB segregation and condensation protein B Cell division −2.72
SACOL1624 era GTP-binding protein Era −2.46
SACOL1538 scpA segregation and condensation protein A −2.31
SACOL1184 NA exfoliative toxin, putative Toxin production and resistance −2.14
SACOL0746 norR transcriptional regulator, MarR family −2.06
SACOL2731 NA cold shock protein, CSD family Adaptations to atypical conditions −2.06
SACOL1383 mscL large conductance mechanosensitive channel protein −1.96
SACOL2024 agrD accessory gene regulator protein D Pathogenesis −1.91
SACOL0610 sdrE sdrE protein Cell adhesion −1.89
SACOL1410 femA femA protein Toxin production and resistance −1.76
SACOL0765 saeS sensor histidine kinase SaeS Pathogenesis −1.69
SACOL0245 lytS sensor histidine kinase LytS −1.66
SACOL1198 ftsA cell division protein FtsA Cell division −1.53
Upregulated Genes
SACOL1943 vraS sensor histidine kinase VraS Toxin production and resistance 5.22
SACOL1450 arlS sensor histidine kinase ArlS Pathogenesis 4.74
SACOL2353 tcaR transcriptional regulator TcaR Toxin production and resistance 4.18
SACOL0672 sarA staphylococcal accessory regulator A 4.11
SACOL2157 NA drug resistance transporter, EmrB/QacA subfamily 3.75
SACOL1451 arlR DNA-binding response regulator ArlR Pathogenesis 3.61
SACOL2289 sarY staphylococcal accessory regulator Y Toxin production and resistance 3.21
SACOL2258 sarV staphylococcal accessory regulator V 2.87
SACOL1942 vraR DNA-binding response regulator VraR 2.61
SACOL1003 NA negative regulator of competence MecA, putative DNA transformation 2.01
SACOL0608 sdrC sdrC protein Cell adhesion 1.82
Protein fate
Downregulated Genes
SACOL1801 NA peptidase, M20/M25/M40 family Degradation proteins, peptides, and glycopeptides −3.45
SACOL0806 pepT peptidase T −2.89
SACOL2385 NA heat shock protein, Hsp20 family Protein folding and stabilization −2.77
SACOL1946 NA methionine aminopeptidase, type I Protein modification and repair −2.62
SACOL1777 NA serine protease HtrA, putative Degradation proteins, peptides, and glycopeptides −2.42
SACOL0581 secE preprotein translocase, SecE subunit Protein and peptide secretion and trafficking −2.13
SACOL1588 NA proline dipeptidase Degradation proteins, peptides, and glycopeptides −2.12
SACOL2038 NA metalloendopeptidase, putative, glycoprotease family −2.06
Upregulated Genes
SACOL0979 clpB ATP-dependent Clp protease, ATP-binding subunit ClpB Degradation proteins, peptides, and glycopeptides 9.42
SACOL1433 NA peptidase, M20/M25/M40 family 8.7
SACOL2125 NA peptidase, M20/M25/M40 family 7.13
SACOL0570 clpC ATP-dependent Clp protease, ATP-binding subunit ClpC, authentic frameshift 5.92
SACOL1636 dnaJ dnaJ protein Protein folding and stabilization 4.94
SACOL0833 clpP ATP-dependent Clp protease, proteolytic subunit ClpP Degradation proteins, peptides, and glycopeptides 3.72
SACOL1638 grpE heat shock protein GrpE Protein folding and stabilization 3.5
SACOL0968 spsA signal peptidase IA, inactive Protein and peptide secretion and trafficking 2.98
SACOL1637 dnaK dnaK protein Protein folding and stabilization 2.67
SACOL2438 NA endopeptidase, putative Degradation proteins, peptides, and glycopeptides 2.46
SACOL1459 NA peptide methionine sulfoxide reductase, degenerate Protein modification and repair 2.38
SACOL2016 groEL chaperonin, 60 kDa Protein folding and stabilization 2.36
SACOL0556 NA chaperonin, 33 kDa 2.17
SACOL0844 secG preprotein translocase, SecG subunit Protein and peptide secretion and trafficking 2.13
SACOL0969 spsB signal peptidase IB 2.02
SACOL2017 groES chaperonin, 10 kDa Protein folding and stabilization 1.81
a

NA – Gene symbol not available