Skip to main content
. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Mol Cancer Ther. 2012 Feb 8;11(4):963–972. doi: 10.1158/1535-7163.MCT-11-0999

Figure 1. Combination of honokiol and IR inhibits colorectal cancer growth.

Figure 1

A, chemical structure of honokiol. B, HCT116 and SW480 cells were incubated with increasing doses of honokiol (0–50 μM), subsequently irradiated with increasing doses of IR (0–5 Gy), and proliferation was determined. The honokiol-IR combination resulted in a significant dose and time dependent decrease in cell proliferation in both cell lines when compared with untreated controls. Moreover, the combination showed an additive inhibition of proliferation compared to honokiol of IR alone (p<0.017). C, up to 50 μM honokiol and 5 Gy IR does not inhibit proliferation of FHC normal colonic epithelial cells. D, combination of honokiol and IR inhibits colony formation. HCT116 and SW480 cells were incubated with 25 μM honokiol for 24 h and subjected to 5.0 Gy IR. Following this, the cells were allowed to grow and form colonies. The honokiol and IR combination inhibited colony formation and showed that additive effect. Results are representative of three independent experiments.