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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: J Immunol. 2012 Mar 14;188(8):3716–3723. doi: 10.4049/jimmunol.1102920

Figure 5. C1q mediated engulfment of apoptotic cells is dependent on Mer.

Figure 5

Engulfment assays were performed as described in the legend to Figure 1 using wild type (WT) and mertk−/− macrophages. (A and B) C1q-adherent macrophages were fed EAIgG (A) or apoptotic Jurkatcells (B). Bars represent the mean fold change from four to six individual experiments ± SEM. **p< 0.01, two-way ANOVA, Bonferroni multiple comparison tests. (C and D) C1q-dependent engulfment was assessed in WT and C3−/− macrophages. Data is expressed as fold change in phagocytosis relative to control from three independent experiments. Bars represent the mean ± SEM. *p < 0.05, Student’s t test. (E) Cell lysates from WT and mertk−/− macrophages adhered to wells pre-coated with 4 µg/ml HSA, C1q or MBL were analyzed for Mer expression by western blot